Epidermal growth factors (EGFs) are natural proteins found in human plasma that have a series of functions which contribute to maintain healthy skin by enhancing cell regeneration: they stimulate epidermal cell growth, proliferation and differentiation. Young skin has a strong capacity to recover; however, with advancing age our growth factor levels decrease, making it more difficult for our skin to repair the visible signs and damage associated with ageing.
These natural proteins play a key role in maintaining skin firmness and elasticity. In addition to EGF there are over 60 other types of growth factors, such as neuronal growth factors or platelet growth factors. These factors were discovered by Rita Levi-Montalcini, who along with Stanley Cohen received the Nobel Prize in Medicine in 1986 as a result. When cell-activating EGF binds to its specific receptor on the cell surface (EGFR), the receptor sends a message through a complex cascade of signals to the nucleus in the control centre of the cell. In the nucleus, the message is translated into various cellular activities such as protein production and increased genetic activity and cell division.
This important cell activator is composed of two protein binding molecules and two molecules of the mentioned factor, with peptide chainsof up to 53 amino acids, hence the name of the revolutionary SKIN FACTOR 53.
Why do we need growth factors?
These natural substances are produced by skin cells to keep it healthy. They help to repair damaged skin, affording epidermal firmness and elasticity as well as contributing to maintain protective functions.
These substances are not to be confused with growth hormones. Ageing and damage to the skin caused by ultraviolet radiation require growth factors for regeneration. Although the cells of aged skin produce lesser amounts of growth factors than young skin, the levels can be compensated by the regular use of cosmetic products containing high concentrations of growth factors.
Where do the growth factors come from?
The biotechnological advances of the last decade have created a range of sources of growth factors. These factors can be obtained from different human cells cultured in the laboratory (skin cells, bone marrow stem cells, etc.), drawn from blood or obtained from other natural sources such as snails and certain plants. All the cells can produce growth factors, and the composition of the mixture of growth factors generated is ideal for their own health.
Therefore, in order to maintain optimum skin health, the ideal growth factors are those produced by the epidermal cells - fibroblasts - which fundamentally secrete elastin and collagen, as well as glycosaminoglycans that conform the supporting matrix of the dermis.
And... do they really work?
Many clinical studies in the last 15 years have underscored the benefits of topically applied products composed of growth factors.
Clear improvements have been demonstrated in terms of the appearance of expression lines, wrinkles and skin texture and colour. Most of the studies show a visible decrease in crow's feet, with improved skin texture under the eyes, and enhanced general brightness. A study published in 2016 and carried out by the University of Kitasato in Japan has demonstrated the efficacy of cosmetic products containing EGF. The results showed cell proliferation to increase with the use of cosmetic products containing certain amounts of EGF (5mg/100mL) (Yamamoto A, Ohno H, Kuroyanagi Y (2016) Evaluation of epidermal growth factor-incorporating skin care product in culture experiment using human fibroblasts. Open J Regen Med 5: 44–54).
SKIN FACTOR 53 patches afford an effective combination of EGF and hyaluronic acid with potent antioxidant action, and are designed to produce a rapid and visible effect on wrinkles and expression lines. Several clinical studies have analysed the cosmetic effectiveness of SKIN FACTOR 53 patches, with concrete results that demonstrate their capacity to improve the general appearance of the skin.
What are the benefits of EGF?
The benefits of epidermal growth factors on skin are cell stimulation, repair and regeneration, as well as enhancing collagen and elastin production. These effects result in a visible reduction in expression lines and wrinkles, improved skin texture and brightness, with a more firm and uniform appearance, and more lasting hydration.
SKIN FACTOR 53 patches topically apply the best available cell activator, which is found naturally in our body, thereby making the product fully biocompatible. Thanks to its application on the skin, and using the most innovating technology, the skin ageing process can be significantly slowed and detained, elastin and collagen production can be increased once again. This is why cell activators are regarded as the new revolution in skin treatment.
It is preferable for cosmetics containing epidermal growth factors to be applied at night, since that is when the skin produces most collagen and elastin, and when the cell repair process is most intense.
Who should use the SKIN FACTOR 53 products?
The clinical results show that SKIN FACTOR 53 affords benefit for any person with visible signs of facial ageing. While women with early signs of ageing can obtain rapid benefit, the most significant visible skin effects are seen in women with more mature expression lines and wrinkles.